Luteinizing hormone is a kind of glycoprotein gonadotropin secreted by anterior pituitary basophilic cells. It mainly promotes ovulation. Under the synergistic effect of FSH, luteinizing hormone is formed and progesterone is secreted. Generally, the normal value during non-ovulation period is 5-25 mIU/ml, and lower than 5mIU/ml indicates insufficient gonadotropin function, which can be seen in Sheehan's syndrome. High FSH and increased LH indicate ovarian function decline, and LH/FSH≥3 is one of the basis for the diagnosis of polycystic ovary syndrome.
Detection range | sample size | Sample type | Test time |
0.2~160mIU/mL | 60μl | Whole blood / serum / plasma | 15min |
Corresponding items | index | Guiding significance | |
FSH,LH | ↑ | Common in primary gonadal lesions | Such as premature ovarian failure, gonadal dysplasia, primary amenorrhea, primary sexual hypofunction, convoluted seminiferous duct development disorder, complete (true) sexual precocious |
↓ | Mainly seen in pituitary or hypothalamic amenorrhea, incomplete (pseudo) sexual precocious. | ||
Pituitary FSH tumor or LH tumor | Different types of changes in FSH and LH concentrations were observed depending on tumor types | The main manifestations of FSH tumor were increased FSH and normal LH. In patients with LH tumor, LH significantly increased and FSH decreased. | In patients with FSH/LH tumor, both FSH and LH are elevated. |
Concentration of FSH and LH in amenorrhea women | To make effective differentiation between ovarian amenorrhea and pituitary or hypothalamic amenorrhea |
Gynecology, obstetrics, laboratory, oncology, reproductive medicine, genetics, etc
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