D-dimer (D-dimer) is an important marker associated with acute thrombus, and its elevation reflects the increased coagulation and cellulose lytic activity in vivo. It not only reflects the presence or continuous formation of thrombus in vivo, but also reflects the enhancement of cellulose dissolution activity in vivo. D-dimer in cellulose cracking products can reflect thrombolytic activity after thrombus formation, which is very important for the diagnosis and treatment of clinical thrombotic diseases.
D-dimer is derived from the cross-linked fibrin clot dissolved by fibrinolytic enzyme, which mainly reflects the fibrinolytic function. The clinical detection of D-dimer is mainly used in the diagnosis of venous thromboembolism (VTE), deep venous thrombosis (DVT) and pulmonary embolism (PE)
Detection range | sample size | Sample type | Test time |
0.1~10mg/L | 60μl | Whole blood / plasma | 5min |
Acute thrombus forms in the circulatory system | ||
vein | artery | Microvascular circulation |
Deep vein thrombosis (DVT) | Acute coronary syndrome (ACS) apoplexy | Disseminated intravascular coagulation (DIC) |
The range of normal values of different reagents is different, generally <0.3mg/L or <0.5mg/L.
Laboratory, cardiology, ICU, emergency department, pediatrics, operating room
Outpatient with venous thromboembolism | |||
Clinical preassessment | |||
Low/moderately suspicious | Highly suspicious | ||
D-Dimer<0.5mg/L | D-Dimer≧0.5mg/L | ||
Thromboembolism was excluded | Thromboembolism is recommended and requires further testing | ||
Do not need treatment | Clinical auxiliary examination | ||
No thrombosis | thrombosis | ||
Do not need treatment | treatment |
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