Serum amyloid A (SAA) is an acute phase reaction protein secreted by the liver, which exists in trace amount in the blood of healthy people. When virus or bacterial infection occurs, SAA begins to increase significantly in 3-6 hours, and increases hundreds or even thousands of times in acute state. SAA has a short half-life and can rapidly decline in the recovery period of disease, which is more sensitive than CRP. Combined detection of SAA and CRP can better distinguish the types of infection and improve the diagnostic efficiency of virus infection.
Detection range | sample size | Sample type | Test time |
5~200mg/L | 5μl | Whole blood / serum / plasma | 3min |
Dynamic monitoring
| Sensitive index of virus infection | SAA is more sensitive than CRP when virus is infected. Combined detection of CRP and SAA is beneficial to the identification of early infectious diseases. |
Indicators of graft rejection | SAA is one of the earliest indicators of rejection, and can be used as a sensitive marker for early monitoring of rejection patients. | |
The monitoring index of tumor invasion and metastasis | SAA level is significantly correlated with the active stage, malignant degree, invasion and metastasis of tumor, so it can be used as one of the indicators of dynamic monitoring. | |
Predictors of cardiovascular events | Therefore, SAA can be used as a predictor of cardiovascular events and prognosis | |
Diagnosis index of AA amyloid disease | SAA is a precursor of AA, which plays a key role in the pathogenesis. The high concentration of SAA can be used as an indicator for the treatment and prognosis of the disease |
Index | CRP | SAA |
Time of discovery | 1930 | 1976 |
Clinical features | Bacterial infection increased 30% of the virus infection increased | The virus infection increased significantly Bacterial infection increased significantly The cure rate of infection decreased greatly |
Peak time | Rising period: 4-6 hours Platform period: 24-48 hours Half life: 18 hours | Rising period: 3-6 hours Platform period: 5-6 hours Half life: 50 minutes |
Laboratory, emergency, ICU, Pediatrics / neonatology, respiratory, surgery, hematology, rheumatology and immunology, oncology, Nephrology, etc.
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