The cysteine proteinase inhibitor (CPI) is named cysteine C. Cystatin C in the circulation is only cleared by glomerular filtration. It is an endogenous marker that reflects changes in glomerular filtration rate. It is reabsorbed in the proximal convoluted tubules, but is completely absorbed after reabsorption. Metabolism is decomposed and does not return to the blood. Therefore, its blood concentration is determined by the glomerular filtration rate and does not rely on any external factors, such as gender, age, and diet. It is a reflection of changes in the glomerular filtration rate Ideal endogenous marker.
Detection range | sample size | Sample type | Test time |
0.2~8mg/L | 10μl | Whole blood / serum / plasma | 15min |
Cystatin C | Cystatin C | ||||
creatinine | |||||
GFR(mL/min/1.73m2) | >89 | 60-89 | 30-59 | 15-29 | <15 |
CKD stage | 1 | 2 | 3 | 4 | 5 |
Impaired kidneys with normal/elevated GFR | Mild renal insufficiency | Moderate renal insufficiency | Severe renal insufficiency | End-stage renal disease (ESRD) |
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