Cysteinase proteinase inhibitor (CPI) is named cystatin C. Cystatin C in circulation is removed only through glomerular filtration, which is an endogenous marker reflecting the change of glomerular filtration rate, and reabsorbed in the proximal convoluted tubules, but is metabolized and decomposed completely after reabsorption, and does not return to blood. Therefore, the concentration of cystatin C in the blood is determined by glomerular filtration rate, and does not depend on any external factors, such as gender, age and diet, It is an ideal endogenous marker reflecting the change of glomerular filtration rate.
Detection range | sample size | Sample type | Test time |
0.2~8mg/L | 10μl | Whole blood / serum / plasma | 15min |
Cystatin C | Cystatin C | ||||
creatinine | |||||
GFR(mL/min/1.73m2) | >89 | 60-89 | 30-59 | 15-29 | <15 |
CKD stage | 1 | 2 | 3 | 4 | 5 |
GFR normal / elevated kidney damage | Mild renal insufficiency | moderate renal insufficiency | Severe renal insufficiency | End stage renal disease (ESRD) |
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