Gelatinase-associated lipid transporter (NGAL) is a small molecule protein expressed by neutrophils. NGAL is highly expressed in renal tubular epithelial cells and is released into the urine and blood within 2 hours after acute kidney injury. It has the characteristics of quick reaction, high specificity and little influence by other factors. Therefore, it can be used as a biomarker for early sensitive acute kidney injury and can also be used to predict the diagnosis of sepsis. High concentrations of NGAL can be detected in the urine and blood of patients with chronic kidney disease caused by a variety of diseases, so it can also be used in the diagnosis and monitoring of chronic kidney disease.
Detection range | sample size | Sample type | Test time |
50~5000ng/mL | 10μl | Whole blood / serum / plasma / urine | 10min |
NGAL has powerful functions. In addition to acting as a member of the apolipoprotein family to bind and transport hydrophobic small molecules, NGAL is also involved in inflammation, embryonic development, immune response, chemotaxis, signal transduction and the occurrence and development of a variety of tumors.
NGAL can promote the differentiation of renal progenitor cells into early renal tubular epithelial cells, repair N-cadherin, up-regulate heme oxygenase and inhibit cell death.
Nephrology, surgery, oncology, ICU, pediatrics, cardiology, endocrinology, Urology, etc
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