Serum amyloid A (SAA) is an acute phase reactive protein secreted by the liver. When viral or bacterial infection occurs, SAA will increase significantly within 3 ~ 6 hours, and even hundreds or thousands of times in the acute phase. The half-life of SAA is very short and decays rapidly during rehabilitation. It is more sensitive than CRP. The combined detection of the two can better distinguish the types of infection and improve the diagnostic efficiency of virus infection.
Dynamic monitoring
| Virus infection sensitivity index | SAA is more sensitive than CRP. Combined detection of CRP and SAA is helpful for the diagnosis of early infectious diseases. |
Transplant rejection test index | Studies have shown that SAA is one of the early indicators of rejection and can be used as a sensitive indicator for early detection of graft rejection. | |
Monitoring indexes of tumor invasion and metastasis | SAA increased in different degrees in different tumor patients, and its level was significantly correlated with tumor activity, malignancy, invasion and metastasis, which can be used as one of the dynamic monitoring indicators | |
Predictors of cardiovascular events | The increase of SAA concentration is positively correlated with the possibility of cardiovascular events in healthy people in the future, which can be used as a predictor and prognostic index of cardiovascular events. | |
Diagnostic index of AA amyloidosis | SAA is a precursor of AA and plays a key role in the pathogenesis of AA. Serum SAA maintained at a high concentration for a long time can be used as an indicator of SAA treatment and prognosis |
Index | CRP | SAA |
Time of discovery | 1930 | 1976 |
Clinical features | Increase bacterial infection | Virus infection increased significantly |
Peak time | Rise time: 4-6 hours | Rise cycle: 3-6 hours |
Laboratory, emergency, ICU, Pediatrics / neonatology, respiratory, surgery, hematology, rheumatology and immunology, oncology, Nephrology, etc.
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