Serum amyloid A (SAA) is an acute-phase-reactive protein that is secreted by the liver.When viral or bacterial infection occurs, SAA increases significantly within 3 to 6 hours, which can increase hundreds of fold in the acute phase.The SAA has a short half-life and decays rapidly during recovery.It is more sensitive than the CRP.The combination of the two can better distinguish between infection types and improve the diagnostic efficiency of viral infection.
Detection range | sample size | Sample type | Test time |
5~200mg/L | 5μl | Whole blood / serum / plasma | 3min |
Dynamic monitoring
| Virus infection sensitivity index | The SAA is more sensitive than the CRP.Combined detection of CRP with SAA contributes to the detection of early infectious disease. |
Transplant rejection test indicators | It have shown that SAA is one of the early indicators of rejection as a sensitive indicator for early detection of graft rejection. | |
Monitoring indicators of tumor invasion and metastasis | SAA has been elevated to varying degrees in patients with various tumors, and its levels are significantly associated with tumor activity, malignancy, invasion, and metastasis, and can be used as one of the indicators of dynamic monitoring | |
Predictors of cardiovascular events | Increased SAA concentrations are positively correlated with the likelihood of future cardiovascular events in healthy people, so SAA can serve as a predictor and prognostic indicator of cardiovascular events. | |
Diagnostic indicators of AA amyloidosis | SAA is a precursor to AA and plays a key role in the pathogenesis.Long-term maintenance of serum SAA levels at high concentrations can be used as an indicator of treatment and SAA prognosis |
Index | CRP | SAA |
Time of discovery | 1930 | 1976 |
Clinical features | Increased bacterial infection Viral infection was increased by 30% | Viral infection was significantly increased Bacterial infections have increased substantially The cure rate of infection decreased significantly |
Peak time | Rising time: 4-6 hours Platform cycle: 24-48 hours Half-life: 18 hours | Rising Period: 3-6 hours Platform Cycle: 5-6 hours Half-life: 50 minutes |
Laboratory, emergency, ICU, Pediatrics / neonatology, respiratory, surgery, hematology, rheumatology and immunology, oncology, Nephrology, etc.
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