The isoenzyme troponin I/myoglobin/creatine kinase (cTnI/Myo/CK-MB) includes the following three indicators: The combined detection of troponin I (cTnI), myoglobin (Myo) and creatine kinase isoenzyme (CK-MB) is of great importance for the Early diagnosis of acute myocardial diseases such as AMI
American Society for Clinical Biochemistry ( NACB ) Practice Guide
Signs of myocardial necrosis should be detected in all patients with ACS
Troponin is a key marker in the diagnosis of myocardial infarction
Myoglobin binding specific markers of myocardial necrosis (eg, cTnI/CK-MB) may help clear or diagnose myocardial infarction more quickly.
MYO | CK-MB | cTnI | |
molecular weight | 17.8KD | 86KD | 22.5KD |
Rise time | 1-2h | 4-6h | 3-6h |
Peak time | 6-9h | 24h | 12-16h |
recovery time | 18-30h | 2-3d | 4-10d |
Clinical value | 1. The most important AMI map was released in the first stage | 1. Font size or re-launch | 1. Preferential signs for diagnosing AMI |
Detection range | sample size | Sample type | Test time | ||
cTnI | MYO | CK-MB | 60μl | Whole blood / serum / plasma | 15min |
0.1~50ng/mL | 10~200ng/mL | 0.8~100ng/mL |
Possibility of outcome | |||
cTnI | CK-MB | MYO | Clinical possibility |
+ | + | + | Myocardial infarction / myocardial injury can basically be diagnosed and the time of onset is 12-24 hours. |
+ | + | - | It can basically be diagnosed as a myocardial infarction injury / myocardial infarction injury, and the detection time is more than one day that has passed during the myocardial identification window. |
+ | - | - | Myocardial damage occurs for a few days and should be rechecked in a few hours. |
+ | - | + | In patients with hepatic myocardial injury, symptoms may last for more than three days, and in patients with re-injury or necrotic areas due to blood clots. |
- | + | + | In early myocardial ischemia, liver myocardial injury following monitoring of CTNI in 4-8 hours is recommended. |
- | - | + | It is recommended to check CTNN in 4-8 hours. |
The reserves can be caused by other diseases such as creative work, musculoskeletal injuries, and liver and kidney disease. | |||
- | + | - | For minor myocardial injury, we recommend CT monitoring in 4-8 hours. |
It may not be myocardial injury and the test time was through my window. | |||
- | - | - | The possibility of ischemic myocardial injury is generally ruled out. When in doubt, it is recommended to check every two to four hours. |
Emergency outpatient departments, Cardiovascular Examination Centers, ICUs and Chest Pain Centers
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