hpbcd 128446-35-5 Hydroxypropyl Beta Cyclodextrin HPBCD synthetic drugs pharmaceutical excipients medicine and drugs

(1). In medicine field

1.2-Hydroxypropyl Beta Cyclodextrin can increase the solubility of the medicine and biological availability, also add up the good effect and decrease the dose.

2.Meanwhile, it control or adjust the reactive speed, lower the drug toxicity and enhance the stability of drugs.

3.Moreover, 2-HP Beta CD is for oral solution with the highest safety.

(2).In food field

1.2-Hydroxypropyl beta cyclodextrin can prevent evaporation of volatile substances, maintaining the stability of its nutrition, get rid of the terrible smell and can significantly enhance the effects of emulsification with the combined use of food emulsifiers.

2.2-HP Beta CD can also make food preservative release slowly, raise the effect of anti-corrosion and extend the shelf life of food.

(3)In the field of cosmetic

1. 2-Hydroxypropyl Beta Cyclodextrin is used as stabilizers, emulsifiers, deodorant in cosmetic.

2. 2-Hydroxypropyl Beta Cyclodextrin can decrease the stimulating effect on the skin produced by organic composition of cosmetic.

3. 2-Hydroxypropyl Beta Cyclodextrin can prevent nutrient ingredient evaporating and oxidating, increase water-soluble of spices and essence, keep fragrance's sustained and release lasting.

Use of 2-hydroxypropyl-beta-cyclodextrin as a solubilizing and stabilizing excipient for protein drugs.

Abstract

A chemically modified, amorphous beta-cyclodextrin, namely, 2-hydroxypropyl-beta-cyclodextrin (HPCD), was examined as a solubilizing and stabilizing agent for protein drugs. The aqueous solubility of ovine growth hormone at pH 7.4 was increased through the use of HPCD. This effect was manifested by higher UV transparency at 600 nm. Interleukin-2 (IL-2) is rendered insoluble upon lyophilization in the absence of stabilizers. Use of aqueous HPCD provides a clear solution, as indicated by fluorometric light scattering, and inhibits aggregate formation, as shown by ultracentrifugation and Western blot analyses. In addition, there were no major conformational changes of IL-2 in HPCD formulation as indicated by fourth-derivative ultraviolet spectroscopy. Finally, IL-2 retained 100% of its biopotency when prepared in HPCD solutions. Aggregation of insulin was also suppressed by HPCD. These data, as well as the i.v. safety of HPCD and its well-characterized chemical composition, suggest that this starch derivative may be a potentially useful excipient for protein drugs intended for parenteral use.

Company profile

Shandong Binzhou Zhiyuan Biotechnology Co.,Ltd. is a leading manufacturer and supplier with derivatives of cyclodextrin product and technology portfolio encompassing a wide range of applications.

Now we have the most advanced domestic production lines: Hydroxypropyl beta cyclodextrin, Sulfobutyl ether beta cyclodextrin Sodium, Methy cyclodextrin, Mercapto cyclodextrin, Amino cyclodextrin, Ethanediamine Cyclodextrin,Piroxicam cyclodextrin, cyclodextrin polymers etc. Also synthesis custom designed cyclodextrin derivatives.

we have Ion chromatograph (IC), Capillary electrophoresis (CE), High performance liquid chromatograph (HPLC), Gas chromatograph (GC), Fourier transform infrared spectroscopy (FTIR) and other imported advanced testing equipments. Multiple means of analysis and inspection help us ensure production quality and accelerate new production developing.

We are particularly focusing and elaborating on the niche products and services ignored by the traditional larger suppliers in the market:

l We customize our products routinely to meet customers' unique requirements;

l We specialize in sourcing difficult-to-find chemicals and delivering them to our customers quickly and efficiently;

l We expand our business by identifying and capitalizing on opportunities for novel products and techniques at early stage;

l We maintain cost structure low to accommodate customers' budgets.

We satisfy our customers with the highest quality products, services, technical and commercial supports. Whether you are looking for a hard-to-find product, an existing product with new specifications, or a new form of a known material, we can meet your challenges in a reliable, efficient and cost effective manner.

We are poised to meet your next challenge.

We specializing in the production of all kinds of characteristics of cyclodextrin derivatives,sush as below:

Sulfobutyl Ether-β-cyclodextrin Sodium Salt CAS: 182410-00-0

Hydroxypropyl-β-cyclodextrin CAS:128446-35-5

Hydroxypropyl-γ-cyclodextrin CAS:128446-34-4

Methyl Beta Cyclodextrin CAS:128446-36-6

2,6-di-O-Methyl Beta Cyclodextrin CAS: 51166-71-3

Carboxymethyl-β-Cyclodextrin sodium salt CAS: 218269-34-2

Piroxicam Beta Cyclodextrin CAS:96684-39-8

mono-(6-amino-6-deoxy)-β-cyclodextrin CAS:29390-67-8

mono-(6-p-toluenesulfonyl)-β-cyclodextrin CAS:67217-55-4

mono-(6-ethanediamine-6-deoxy)-β-Cyclodextrin CAS:60984-63-6

mono-(6-Mercapto-6-deoxy)-β-Cyclodextrin CAS:81644-55-5

Mono-(6-azido-6-deoxy)-β-Cyclodextrin CAS:98169-85-8

α-cyclodextrins, Alfadex CAS:10016-20-3

γ-cyclodextrin CAS:17465-86-0

β-cyclodextrin, cyclomaltoheptaose CAS: 7585-39-9

mono-(6-(1,6-hexamethylenediamine) CAS:131991-61-2

-6-deoxy)-β-Cyclodextrin

Any related inquiry, pls contact with us.

Sincerely

Terry

Shandong Binzhou Zhiyuan Biotechnology Co., Ltd

Boxing Economic Development Zone,Binzhou city,Shandong,China

Cell : +86 15254382393

Tel : +86 543 2616568

Skype: terrygu0828

E-mail: zyswterrygu@163.com