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Overview

What is Micro Hyperbaric Oxygen Therapy?

Micro Hyperbaric Oxygen Therapy (MHBOT) represents an innovative medical intervention that involves administering a highly concentrated mixture of oxygen, typically reaching a purity of 96%, under conditions of elevated pressure exceeding standard atmospheric pressure (1 ATA). This specialized therapy enables patients to inhale pure or nearly pure oxygen within a pressurized chamber, where the increased pressure significantly enhances the oxygen's solubility within the bloodstream and bodily tissues.

This enhanced solubility allows for greater penetration of oxygen into the deepest layers of the body, including areas where blood flow may be compromised due to injury, disease, or other conditions. As of 2021, China stands as a global leader in the adoption of MHBOT, with 2,107 hospitals across the mainland, Hong Kong, Macau, and Taiwan equipped with medical-grade hyperbaric oxygen chambers. Nationwide, there are over 5,600 of these chambers, underscoring the widespread use and acceptance of this therapy as a valuable clinical tool. The sheer number of chambers and patients treated annually places China at the forefront of hyperbaric oxygen therapy worldwide.

2019 Nobel Prize in Physiology or Medicine Results Explained

Oxygen utilisation and regulation are essential for the survival of higher life, and three scientists, William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza, have been awarded the 2019 Nobel Prize in Physiology or Medicine for their discovery of a mechanism related to cellular sensing and adaptation to oxygen availability. They discovered that hypoxia-inducible factor 1 (HIF-1) is widely present in acute and chronic hypoxic cells and is an important transcription factor for cellular adaptation to hypoxia.HIF-1 levels are regulated by oxygen content. Under hyperoxia, HIF-1 is modified and then degraded; under hypoxia, HIF-1 is not degraded and causes the expression of hypoxia-related genes, such as erythropoietin, through transcriptional regulation. This article introduces the discovery and basic molecular mechanism of HIF-1, and discusses its value in clinical application.

The major discovery of William G. Kaelin Jr, Sir Peter J. Ratcliffe and Gregg L. Semenza in the pathway of hypoxia-inducible factor has laid the foundation for the study of the mechanism of cellular adaptation to hypoxia and opened a whole new horizon for researchers, which will pave the way for research and treatment of a variety of diseases such as anaemia, tumours and ischemic-hypoxic diseases. mechanism of anaemia, tumour and ischemic-hypoxic diseases, paving the way for research and treatment. Subsequent studies have broadened the regulatory network of the HIF pathway, and through a large number of scientific experiments and clinical studies, a variety of therapeutic drugs have been developed, bringing a new turn to the prevention and treatment of diseases. With scientists' further understanding of the mechanism of hypoxia adaptation, the research results in this field will also be applied to the treatment of more diseases.

As an advanced medical equipment, the benefits of hyperbaric oxygen chamber are mainly reflected in the following aspects:

1.Elevating Body Oxygen Levels

Principle: A hyperbaric oxygen chamber operates by pressurizing oxygen, enabling individuals to breathe in oxygen concentrations within the chamber that far exceed normal environmental levels, often achieving concentrations four times higher than usual. This high-pressure, high-oxygen atmosphere substantially boosts the body's oxygen content.

Function: Elevating blood oxygen levels holds significant therapeutic value in treating conditions like carbon monoxide poisoning and brain edema. Additionally, it stimulates cellular aerobic metabolism and exhibits inhibitory effects on the growth and reproduction of anaerobic bacteria, thus serving an anti-infectious purpose.

2. Improve drug efficacy
Mechanism: Hyperbaric oxygen chamber therapy can improve the therapeutic effect of some drugs, such as antibiotics, antiviral drugs, etc. By increasing the body's oxygen content, it can promote the drugs to work better, thereby accelerating the recovery of the disease.

3. Promote nerve regeneration
Function: When the body is deficient in oxygen, it will cause brain damage. Hyperbaric oxygen chamber treatment can improve the blood supply to the brain, repair damaged nerve tissue, and promote nerve regeneration. This is useful for the treatment of cerebral hemorrhage, cerebral infarction, cerebral palsy, etc. Diseases play an important role.

4. Regulate immune function
Effect: Hyperbaric oxygen chamber therapy can accelerate the repair of damaged cells and improve the immune function of patients, which is of great significance to enhance the resistance of patients and prevent and treat infectious diseases.

5. Treatment of specific diseases
Indications: Hyperbaric oxygen chamber has a wide range of indications, including harmful gas poisoning (such as carbon monoxide poisoning), neurological diseases (such as hypoxic-ischemic brain injury), anaerobic bacterial infections, etc. Through hyperbaric oxygen chamber treatment, it can significantly Improve the prognosis and quality of life of patients.

6. Other benefits

Safety: The air pressurized cabin can accommodate multiple people and is divided into single cabin and multi-person cabin. The pressurized medium is air, so it is safer. Although the pure oxygen pressurized cabin can only accommodate one person for treatment, it is not necessary to wear a mask during treatment, and it is convenient to inhale oxygen. However, the pure oxygen environment is prone to deflagration, so anti-static measures must be taken when entering the cabin.

Personalized treatment: When using hyperbaric oxygen chamber therapy, it is necessary to decide the treatment plan according to the patient's specific situation, and closely monitor the patient's physical condition to prevent the occurrence of adverse reactions.

There are some other noteworthy benefits of hyperbaric chambers:

1. Relieve pain and swelling
Principle: The hyperbaric oxygen chamber can reduce the inflammatory response by providing a high-concentration oxygen environment, thereby relieving pain and swelling. In patients with certain inflammatory diseases or excessive inflammatory response after infection, high-concentration oxygen can inhibit the inflammatory response and promote the patient's recovery.

2. Promote wound healing
Function: Hyperbaric oxygen chamber has a significant effect on promoting wound healing for refractory wounds, such as diabetic foot and burn wounds. High concentration of oxygen can promote cell regeneration and division, improve the body's metabolic level, and thereby speed up wound healing. In addition, the hyperbaric oxygen chamber can also accelerate the aggregation and coagulation of platelets, promote the re-growth of wound blood vessels, and accelerate the process of wound healing.

3. Improve intelligence and work efficiency
Effect: Insufficient oxygen supply can lead to fatigue syndrome, which is manifested as inattention, memory loss, work efficiency reduction, etc. Hyperbaric oxygen chamber therapy can significantly improve these symptoms, by increasing the body's oxygen content and improving the oxygen supply to the brain, thereby improving intelligence and work efficiency.

There are some other noteworthy benefits of hyperbaric chambers:
1. Antibacterial effect
The high-concentration oxygen environment provided by the hyperbaric oxygen chamber has a killing effect on certain bacteria, fungi and viruses. By increasing the oxygen concentration, the living environment of microorganisms can be changed, thus reducing the number of bacteria, inhibiting their growth and reproduction, and playing an antibacterial role. This is of great significance for the prevention and treatment of infectious diseases.

2. Improve blood circulation
Hyperbaric oxygen chamber can increase the solubility of oxygen in the body and increase the concentration of oxygen in the blood, thereby improving the oxygen supply capacity of the blood. For patients with poor blood circulation or insufficient oxygen supply, hyperbaric oxygen chamber can promote blood circulation and increase the oxygen supply to vital organs such as the heart and brain, helping to relieve various symptoms caused by hypoxia.

3. Eliminate fatigue and improve body resistance
Insufficient oxygen supply can lead to fatigue syndromes such as insufficient physical strength, physical weakness, dizziness, insomnia, memory loss, and loss of appetite. By providing sufficient oxygen, hyperbaric oxygen chambers can significantly improve these symptoms, eliminate fatigue, improve the body's resistance and immunity, and help prevent the occurrence of diseases.

4. Promote post-exercise recovery
For athletes or people who regularly engage in physical exercise, hyperbaric oxygen chamber can promote physical recovery after exercise. By improving the body's oxygen supply capacity, accelerating the discharge of metabolic waste and the repair of muscle tissue, it can help relieve muscle soreness and fatigue, improve sports performance and recovery speed.