Alzheimer's Disease N-F—AD7c-NTP in POClia

Alzheimer's disease (AD) is a central nervous system degenerative disease characterized by progressives cognitive impairment, which leads to the fifth major cause of death among the elderly, and there is no special effective treatment yet. AD7C-NTP is a transmembrane phosphoprotein closely related to the degeneration of AD neurons, which can promote the germination of neuroinflammation and apoptosis. It is selectively elevated in the brain tissue, cerebrospinal fluid and urine of patients with AD in the early stage. However, similar specific increase has not been found in multiple sclerosis, depression, and other chronic diseases.The sensitivity and specificity of AD7C-NTP in urine for the diagnosis of AD were similar to those in cerebrospinal fluid, and the content of AD7C-NTP in urine was positively correlated with the severity of dementia. In addition, urine detection is easy to operate, non-invasive, economic, safe, and other advantages, convenient for clinical application, urine AD7c-NTP may become a specific biomarker for screening and diagnosis of AD in the future.

EXPLANATION OF THE TEST

The Alzheimer-related neurofilament protein AD7c-NTP, belonging to the neurofilament protein family, is elevated in the brain tissue, cerebrospinal fluid and urine of early AD patients, and is significantly correlated with neuronal degeneration and damage. Its content is proportional to the severity of dementia, and these characteristics make it an important marker for the early diagnosis of AD.
Its biggest advantage is that it can detect changes in AD7c-NTP levels in urine, overcoming the shortcomings of various invasive tests.

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